string_ppi_enrichment
ActiveTool of STRING Database MCP Server
This tool tests if your network is enriched in protein-protein interactions compared to the background proteome-wide distribution (i.e., if your proteins are more functionally connected than expected by chance). - The enrichment is assessed using the actual observed edges versus expected edges in a random network of the same size. - The p-value reflects the likelihood that your observed number of interactions would occur by chance. - Report the p-value as a human-readable value (e.g. 2.3e-5 or 0.023). When calling related tools use the same input parameters unless otherwise specified. Output fields: - number_of_nodes: Number of proteins in your network - number_of_edges: Number of observed edges/interactions - average_node_degree: Mean degree (average number of interactions per node) - local_clustering_coefficient: Average clustering coefficient in the network - expected_number_of_edges: Expected number of edges in a random network of the same size - p_value: p-value for network enrichment (smaller = more enriched) Example identifiers: "SMO%0dTP53"
Parameters schema
{
"type": "object",
"required": [
"identifiers"
],
"properties": {
"species": {
"anyOf": [
{
"type": "string",
"description": "Required. NCBI/STRING taxon (e.g. 9606 for human, or STRG0AXXXXX for uploaded genomes)."
},
{
"type": "null"
}
],
"default": null
},
"identifiers": {
"type": "string",
"description": "Required. One or more protein identifiers, separated by %0d. Example: SMO%0dTP53"
},
"required_score": {
"anyOf": [
{
"anyOf": [
{
"type": "integer",
"maximum": 1000,
"minimum": 0
},
{
"type": "null"
}
],
"description": "Optional. Minimum interaction confidence score. Omit unless a confidence threshold is requested or a broader/narrower threshold is needed."
},
{
"type": "null"
}
],
"default": null
}
}
}No endpoints wrapped at confidence ≥ 0.70.
Parent server
STRING Database MCP Server
https://github.com/meringlab/string-mcp
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