ensembl_get_homology
ActiveTool of io.github.cyanheads/ensembl-mcp-server
declared in 0.4.0
Find orthologs and/or paralogs of a gene across species. Returns each homolog's stable ID, species, homology type (ortholog_one2one, ortholog_one2many, paralog_many2many, etc.), perc_id (percent identity), perc_pos (percent positives), and taxonomy level. Essential for cross-species research — for example, "what is the mouse equivalent of human TP53?" or "how conserved is BRCA2 across mammals?". Provide either symbol + species or a stable gene ID. Target species can be filtered to a single species or left open to return all available homologs.
Parameters schema
{
"type": "object",
"$schema": "http://json-schema.org/draft-07/schema#",
"properties": {
"id": {
"type": "string",
"description": "Ensembl stable gene ID (e.g. ENSG00000139618). Use ensembl_lookup_gene to get the stable ID from a symbol. Cannot be combined with symbol."
},
"type": {
"enum": [
"orthologues",
"paralogues",
"all"
],
"type": "string",
"default": "orthologues",
"description": "Type of homologs to return. orthologues: genes related by speciation (cross-species equivalents). paralogues: genes related by duplication (within or across species). all: both orthologs and paralogs."
},
"symbol": {
"type": "string",
"description": "Gene symbol in the source species (e.g. BRCA2, TP53). Species defaults to homo_sapiens; set species for other organisms. Cannot be combined with id."
},
"species": {
"type": "string",
"default": "homo_sapiens",
"description": "Source species (the species the query gene belongs to) in Ensembl internal format. Default is homo_sapiens. Use ensembl_list_species to discover valid values."
},
"target_species": {
"type": "string",
"description": "Filter to homologs in a single target species (e.g. mus_musculus for mouse). Omit to return homologs across all available species. Use ensembl_list_species to discover valid values."
}
}
}Parent server
io.github.cyanheads/ensembl-mcp-server
https://github.com/cyanheads/ensembl-mcp-server
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