aso_design

Active

declared in 1.1.0

Design antisense-oligonucleotide (ASO) gapmers against an mRNA target: scans candidate sites, builds the antisense oligo in the standard 5-10-5 architecture (chemically-modified wings, central DNA gap for RNase H1, phosphorothioate backbone), and screens each for known liabilities (G-quadruplex motifs, CpG immunostimulation, self-complementarity, GC extremes). No transcriptome-wide off-target search.

Parameters schema

{
  "type": "object",
  "required": [
    "target"
  ],
  "properties": {
    "wing": {
      "type": "integer",
      "default": 5,
      "description": "Modified-wing length on each side (nt); the central gap = length − 2×wing."
    },
    "length": {
      "type": "integer",
      "default": 20,
      "description": "Total gapmer length (nt)."
    },
    "target": {
      "type": "string",
      "description": "Nucleotide sequence (raw or FASTA; IUPAC accepted)."
    }
  },
  "additionalProperties": false
}

What this tool wraps· 0 endpoints

min confidence0.70 0.50

No endpoints wrapped at confidence ≥ 0.70.

Parent server

com.seqbench/workbench

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